Once you've entered Volcano Manor, Tanith will give you your first task: a list of Elden Ring Runes targets you must track down and eliminate. This marks the start of the Volcano Manor Assassinations, where you'll hunt specific NPCs who are scattered throughout the world. These assassination targets are key to progressing the questline and unlocking new Elden Ring Items and abilities.
Some of the targets are tough, especially if you're under-leveled. However, they will yield Elden Ring Runes upon defeat and may drop valuable items like weapons, armor, and key lore items that are essential for progressing with the quest. You can find these targets in various locations, including Lirunia of the Lakes, Liurnia of the Lakes, and Caelid. Be sure to read the description of each target carefully, as the questline provides clues that lead you toward their locations.
The assassinations themselves are not always straightforward. Some NPCs are hidden in difficult-to-reach areas, requiring you to solve puzzles or defeat other powerful enemies to gain access. The key here is exploration: keep an eye out for areas that seem out of place or require you to activate certain platforms or mechanisms to Elden Ring Runes buy reach your goal.